Arch Pathol Lab Med. 1978 Oct;102(10):497-501.

Clinical significance of an increased or decreased serum alkaline phosphatase level.

Abstract

An increase in the level of serum alkaline phosphatase (ALP) may be caused by a wide variety of pathologic lesions that involve multiple organs, since the enzyme is an ubiquitous one. Before one attempts to identify a significant pathologic abnormality, the clinician should consider the possibility of a physiologic or spurious cause for an increased level of ALP. A decreased ALP level also has diagnostic value.

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